The experimental study of mouse liver in magneto-acousto-electrical tomography by scan mode

Phys Med Biol. 2020 Nov 5;65(21):215024. doi: 10.1088/1361-6560/abb4bb.

Abstract

Magneto-acousto-electrical tomography (MAET) is an imaging method coupled with sound field and magnetic field. The aim of this study is to present some novel experimental results of the mouse liver for the magneto-acousto-electrical tomography measured by two electrodes. The magnetic field in the space of 60 mm3 is about 300 mT which generate by two permanent magnets. A plane transducer with 2.25 MHz center frequency is utilized to generate acoustic waves inside the object. The signal is detected by two similar 1 mm copper foil electrodes. An amplifier is designed to receive the MAET signal, and the gain of the amplifier is adjusted to be 54 dB. The phantom used in this paper is a mouse liver surrounded by a gel phantom with the conductivity of 0.7 S m-1. The gel phantom with the conductivity of 0.7 S m-1 is used to simulate the liver tumor, and the normal mouse liver is filled in the phantom. A series of the MAET signals are detected by the electrodes when the transducer is moved on a pre-set line route, then a B-scan image is realized. The experimental system can provide more information about the tumor and the results show that the MAET is sensitive enough for the potential clinical application of tumor in animal or human.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustics*
  • Algorithms
  • Animals
  • Electric Conductivity
  • Electricity*
  • Electrodes
  • Liver / diagnostic imaging*
  • Magnetic Fields*
  • Mice
  • Phantoms, Imaging
  • Tomography / instrumentation
  • Tomography / methods*
  • Transducers