Regional disease control in sinonasal mucosal melanoma: Systematic review and meta-analysis

Armando De Virgilio; Andrea Costantino; Federica Canzano; Remo Accorona; Giuseppe Mercante; Fabio Ferreli; Luca Malvezzi; Giovanni Colombo; Raul Pellini; Giuseppe Spriano

doi:10.1002/hed.26537

Regional disease control in sinonasal mucosal melanoma: Systematic review and meta-analysis

Head Neck. 2021 Feb;43(2):705-715. doi: 10.1002/hed.26537. Epub 2020 Nov 5.

Authors

Armando De Virgilio^{1

2}, Andrea Costantino^{1

2}, Federica Canzano¹, Remo Accorona³, Giuseppe Mercante^{1

2}, Fabio Ferreli¹, Luca Malvezzi¹, Giovanni Colombo¹, Raul Pellini⁴, Giuseppe Spriano^{1

2}

Affiliations

¹ Otorhinolaryngology Unit, IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano (MI), Italy.
² Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele (MI), Italy.
³ Department of Otorhinolaryngology - Head and Neck Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
⁴ Department of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

PMID: 33151611
DOI: 10.1002/hed.26537

Abstract

Purpose: To systematically analyze the regional disease control after sinonasal mucosal melanoma (SNMM) primary treatment.

Methods: The study was performed according to the PRISMA guidelines searching on Scopus, PubMed/MEDLINE, Cochrane Library, and Google Scholar databases.

Results: A total of 15 studies with 936 patients (median age: 68.0 years, IQR 65-71) were included. Overall, the cumulative regional recurrence rate (RRR) was 18.4% (n = 917, 99% CI: 14.0%-23.4%), with a median follow-up of 30.0 months (n = 765, IQR 22.0-37.0). The RRR in clinical node negative patients was 17.0% (99% CI: 12.2%-22.5%), with a median follow-up of 22.0 months (n = 327, IQR 21.5-31.5).

Conclusions: The RRR of SNMM after primary treatment is not to be neglected. Further prospective studies should be encouraged to clarify if elective treatment of the neck could be recommended at least in a subgroup of patients.

Keywords: elective treatment; lymph node; mucosal melanoma; neck dissection; sinonasal.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Aged
Head and Neck Neoplasms*
Humans
Melanoma* / therapy
Mucous Membrane
Neoplasm Recurrence, Local
Prospective Studies