For decades, the histologic evidence about osseointegration and the bone-implant interface has been discussed in the literature. In this review, the effectiveness of dental implants retrieved for different causes was evaluated. A literature search was performed in databases for papers about implants retrieved from humans published by the Implant Retrieval Center of the University of Chieti-Pescara, Italy. Sixty-eight articles were selected into categories based on topics. The data indicated high level of bone-to-implant contact, lamellar bone close to the surface, roughness related to an increased bone response, organized and remodeled bone after loading, and peri-implant interfaces subjected to a continuous dynamic function.