Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

Chem Commun (Camb). 2020 Nov 19;56(92):14491-14494. doi: 10.1039/d0cc05125j.

Abstract

An intelligent nitric oxide gas-releasing nanoplatform based on CuS-nanoplates has been designed to overcome the heat endurance of tumor cells by the inhibition of HSP90 expression with the released NO gas in mitochondria and thereby realize enhanced PTT under mild temperature conditions.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Copper / chemistry*
  • Drug Liberation
  • Gene Expression Regulation / drug effects
  • HSP90 Heat-Shock Proteins / genetics
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Hyperthermia, Induced
  • Infrared Rays
  • Mitochondria / metabolism*
  • Nanocapsules / chemistry*
  • Nitric Oxide / chemistry*
  • Nitric Oxide / pharmacology
  • Organophosphorus Compounds / chemistry
  • Photothermal Therapy
  • Polyethyleneimine / chemistry
  • Sulfides / chemistry*
  • Theranostic Nanomedicine

Substances

  • Antineoplastic Agents
  • HSP90 Heat-Shock Proteins
  • Nanocapsules
  • Organophosphorus Compounds
  • Sulfides
  • Nitric Oxide
  • Copper
  • Polyethyleneimine