Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Giuseppe Gangarossa; Serge Luquet

doi:10.1016/j.cmet.2020.10.003

Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?

Cell Metab. 2020 Nov 3;32(5):701-703. doi: 10.1016/j.cmet.2020.10.003.

Authors

Giuseppe Gangarossa¹, Serge Luquet²

Affiliations

¹ Université de Paris, BFA, UMR 8251, CNRS, 75013 Paris, France.
² Université de Paris, BFA, UMR 8251, CNRS, 75013 Paris, France. Electronic address: serge.luquet@u-paris.fr.

PMID: 33147483
DOI: 10.1016/j.cmet.2020.10.003

Abstract

Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al. (2020) now report that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmeshes GABAergic neurons, is reversibly altered in diabetic rats and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Diabetes Mellitus, Experimental*
Extracellular Matrix
Fibroblast Growth Factor 1*
Homeostasis
Hypothalamus
Rats

Substances

Fibroblast Growth Factor 1