GABA-enriched teas as neuro-nutraceuticals

Neurochem Int. 2020 Dec:141:104895. doi: 10.1016/j.neuint.2020.104895. Epub 2020 Nov 2.

Abstract

Teas enriched in GABA are consumed for their beneficial effects on blood pressure, stress and anxiety. These effects may involve actions of GABA on the central and peripheral nervous systems. The anaerobic procedures for the production of GABA-enriched teas increase GABA levels by 10-20 times. They also significantly alter the levels of other constituents that may interact with the actions of GABA. These include epigallocatechin gallate, caffeine and theanine. The possible interactions of these active constituents make the understanding of the effects of GABA-enriched teas complex. More data is needed to establish where and how GABA is acting following consumption of GABA-enriched teas. While there is considerable evidence that such GABA is acting on GABA receptors in the periphery, there is rather less evidence that is acting directly in the brain. Certainly, there is more to the action of GABA-enriched teas than GABA itself.

Keywords: Caffeine; Epigallocatechin gallate; GABA; Green tea; Oolong tea; Theanine.

Publication types

  • Review

MeSH terms

  • Animals
  • Dietary Supplements*
  • Humans
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use*
  • Plant Extracts / pharmacology
  • Receptors, GABA / drug effects
  • Receptors, GABA / metabolism
  • Tea*
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / metabolism
  • gamma-Aminobutyric Acid / therapeutic use*

Substances

  • Neuroprotective Agents
  • Plant Extracts
  • Receptors, GABA
  • Tea
  • gamma-Aminobutyric Acid