Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules

Carbohydr Polym. 2021 Jan 1:251:116988. doi: 10.1016/j.carbpol.2020.116988. Epub 2020 Aug 30.

Abstract

Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 ± 0.213 μm), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 ± 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.

Keywords: Chitosan; Controlled release; Formaldehyde; Glutaraldehyde; Microencapsulation; Vitamin E.

MeSH terms

  • Capsules / chemistry
  • Chitosan / chemistry
  • Cosmetics / administration & dosage
  • Cosmetics / pharmacokinetics
  • Cross-Linking Reagents
  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacokinetics
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / pharmacokinetics
  • Desiccation
  • Drug Compounding / methods*
  • Emulsions
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • In Vitro Techniques
  • Kinetics
  • Microscopy, Electron, Scanning
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Vitamin E / administration & dosage*
  • Vitamin E / pharmacokinetics

Substances

  • Capsules
  • Cosmetics
  • Cross-Linking Reagents
  • Delayed-Action Preparations
  • Dermatologic Agents
  • Emulsions
  • Vitamin E
  • dodecyl polyoxyethylene sulfuric acid
  • Polyethylene Glycols
  • Chitosan