Synthesis of resilient hybrid hydrogels using UiO-66 MOFs and alginate (hydroMOFs) and their effect on mechanical and matter transport properties

Hugo H C de Lima; Cleiser T P da Silva; Vicente L Kupfer; Jaqueline de C Rinaldi; Erika S Kioshima; Dalmo Mandelli; Marcos R Guilherme; Andrelson W Rinaldi

doi:10.1016/j.carbpol.2020.116977

Synthesis of resilient hybrid hydrogels using UiO-66 MOFs and alginate (hydroMOFs) and their effect on mechanical and matter transport properties

Carbohydr Polym. 2021 Jan 1:251:116977. doi: 10.1016/j.carbpol.2020.116977. Epub 2020 Aug 27.

Authors

Hugo H C de Lima¹, Cleiser T P da Silva², Vicente L Kupfer¹, Jaqueline de C Rinaldi³, Erika S Kioshima³, Dalmo Mandelli⁴, Marcos R Guilherme⁵, Andrelson W Rinaldi⁶

Affiliations

¹ Rinaldi Research Group, Department of Chemistry, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá, PR, Brazil.
² Rinaldi Research Group, Department of Chemistry, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá, PR, Brazil; Center of Natural and Human Sciences, Federal University of ABC, 5001 Av. dos Estados, Bangu, Santo André, SP 09210-580, Brazil.
³ Postgraduation in Bioscience and Physiopathology - PBF, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá, PR, Brazil.
⁴ Center of Natural and Human Sciences, Federal University of ABC, 5001 Av. dos Estados, Bangu, Santo André, SP 09210-580, Brazil.
⁵ Rinaldi Research Group, Department of Chemistry, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá, PR, Brazil; Faculty of Engineering and Innovation Professional Technical - FEITEP. Av. Paranavaí, 1164, CEP - 87070-130, Parque Industrial Bandeirantes, Maringá - PR, Brazil.
⁶ Rinaldi Research Group, Department of Chemistry, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá, PR, Brazil. Electronic address: awrinaldi@uem.br.

PMID: 33142554
DOI: 10.1016/j.carbpol.2020.116977

Abstract

Herein, we report the preparation of an organic-inorganic hybrid hydrogel architecture using vinyl alginate and UiO-66 MOFs (metal-organic frameworks) modified with acrylic acid (AA) UiO-66AA. UiO-66 MOFs with different crystal sizes (600, 1500, and 2500 nm) were synthesized and the effect on the mechanical and transport properties of the resulting materials, such as water absorption capacity and drug release, were evaluated. HydroMOF showed higher water absorption capacity than the pure hydrogel and enhanced mechanical properties, which depend on crystal size and the amount of UiO-66AA MOF used. The initial release rate of drug (burst release) from hydroMOFs was lower when small-sized crystals or a small amount of large-sized crystals were used; thus these are essential in changing half-life values of release rates. Finally, the cytotoxicity screening successfully showed that hydroMOFs are promising biocompatible compounds proven to have the advantages of minimized burst release and mechanical robustness.

Keywords: Crystal size; Drug delivery; Hybrid material; Mechanical properties; UiO-66 MOF.