Limited Spatial Spread Explains the Dependence of Visual Response Adaptation on Stimulus Size in Rat Superior Colliculus Neurons

Abstract

Although adaptation to light occurs in the eye and mainly preserves the full dynamic range of neuronal responses during changing background illumination, it affects the entire visual system and helps to optimize visual information processing. We have shown recently that in rat superior colliculus (SC) neurons adaptation to light acts as a local low-pass filter because, in contrast to the primate SC, in rat collicular neurons adaptation to small stimuli is largely limited to the vicinity of the adaptor stimulus. However, it was unclear whether large visual stimuli would induce the same spatially limited adaptation. We addressed this question by evaluating the effects of 1.8°, 6.2° and 20.8° wide adaptor stimuli on test stimuli of variable size. Single unit recordings in the adult rat SC were employed to estimate the response amplitude. Small, 1.8° and 6.2° adaptors habituated visual responses only to stimuli smaller than the adaptive stimuli. However, the 20.8° adaptor dramatically reduced responses even to test stimuli >3 times wider than the adaptor (up to 70° wide). The latter result may be explained by a nearly complete occlusion by a large adaptor of the neuron's receptive field (RF). All these results are consistent with the idea of a limited spatial spread of adaptation in rat SC neurons that is the consequence of high convergence of retinal inputs, in which small RFs limit the spatial spread of adaptation. It is concluded that, in this limited spatial spread of adaptation, rodent SC resembles higher visual system areas in primates and indicates potential differences in visual information processing between rodents and primates.

Keywords: information optimization; oculomotor; single-units; visual system.