Abstract
Inspired by the slight acidic microenvironment, a variety of pH-responsive nanomaterials are designed for highly effective antibacterial therapy by improving the ability of drug penetration and retention to enhance the therapeutic efficacy of phototherapy or control surface adhesion. This review summarizes the common pH-responsive modes and highlights the recent and potential applications of pH-responsive nanomaterials in anti-infective therapy. Finally, the challenges and prospects of pH-responsive nanomaterials in clinical transformation are discussed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Anti-Bacterial Agents / administration & dosage*
-
Anti-Bacterial Agents / chemical synthesis*
-
Drug Carriers / administration & dosage*
-
Drug Carriers / chemical synthesis*
-
Drug Resistance, Multiple, Bacterial / drug effects*
-
Drug Resistance, Multiple, Bacterial / physiology
-
Humans
-
Hydrogen-Ion Concentration
-
Nanostructures / administration & dosage*
-
Nanostructures / chemistry*
-
Phototherapy / methods
-
Phototherapy / trends
-
Wound Healing / drug effects
-
Wound Healing / physiology
Substances
-
Anti-Bacterial Agents
-
Drug Carriers