Abrupt Deterioration of COVID-19 Patients and Spreading of SARS COV-2 Virions in the Lungs

N Filipovic; I Saveljic; K Hamada; A Tsuda

doi:10.1007/s10439-020-02676-w

Abrupt Deterioration of COVID-19 Patients and Spreading of SARS COV-2 Virions in the Lungs

Ann Biomed Eng. 2020 Dec;48(12):2705-2706. doi: 10.1007/s10439-020-02676-w. Epub 2020 Nov 2.

Authors

N Filipovic^{1

2}, I Saveljic^{3

4}, K Hamada⁵, A Tsuda⁶

Affiliations

¹ Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, 34000, Kragujevac, Serbia. fica@kg.ac.rs.
² Biomedical Research and Development Center for Bioengineering (BIOIRC), Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia. fica@kg.ac.rs.
³ Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, 34000, Kragujevac, Serbia.
⁴ Biomedical Research and Development Center for Bioengineering (BIOIRC), Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia.
⁵ Department Respiratory Medicine, Nara Medical University, Shijo 840, Kashihara, Nara, 634-8521, Japan.
⁶ Tsuda Lung Research, Shrewsbury, MA, 01545, USA.

Abstract

A unique feature of COVID-19 interstitial pneumonia is an abrupt progression to respiratory failure. Our calculation shows that this abrupt deteriorate may be caused by a sudden shift in the spread of virus-laden bioaerosols through the airways to many different regions of the lungs from the initial site of infection.

Publication types

Letter

MeSH terms

COVID-19* / metabolism
COVID-19* / pathology
COVID-19* / transmission
Humans
Lung* / metabolism
Lung* / pathology
Models, Biological*
SARS-CoV-2 / metabolism*
Virion / metabolism*