Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity

BMJ Case Rep. 2020 Nov 2;13(11):e237168. doi: 10.1136/bcr-2020-237168.

Abstract

As methadone use increases, the potential for methadone-induced cardiotoxicity (MIC) may rise. We describe a case of acute right ventricular (RV) failure leading to cardiogenic shock after methadone overdose. This presentation was followed by full RV recovery. This previously undescribed presentation highlights the challenges involved with MIC, its diagnosis and its management.

Keywords: cardiovascular system; clinical diagnostic tests; heart failure; toxicology.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antitussive Agents / adverse effects
  • Cardiotoxicity
  • Drug Overdose / complications*
  • Drug Overdose / diagnosis
  • Female
  • Heart Failure / chemically induced*
  • Heart Failure / diagnosis
  • Heart Failure / physiopathology
  • Humans
  • Methadone / adverse effects*
  • Middle Aged
  • Tomography, X-Ray Computed
  • Ventricular Function, Right / drug effects*

Substances

  • Antitussive Agents
  • Methadone