Novel Quinoline-Based Thiazole Derivatives for Selective Detection of Fe3+, Fe2+, and Cu2+ Ions

Selvaraj Shyamsivappan; Arjunan Saravanan; Nandakumar Vandana; Thangaraj Suresh; Shanmugam Suresh; Raju Nandhakumar; Palathurai Subramaniam Mohan

doi:10.1021/acsomega.0c03445

Novel Quinoline-Based Thiazole Derivatives for Selective Detection of Fe³⁺, Fe²⁺, and Cu²⁺ Ions

ACS Omega. 2020 Oct 12;5(42):27245-27253. doi: 10.1021/acsomega.0c03445. eCollection 2020 Oct 27.

Authors

Selvaraj Shyamsivappan¹, Arjunan Saravanan², Nandakumar Vandana¹, Thangaraj Suresh¹, Shanmugam Suresh³, Raju Nandhakumar³, Palathurai Subramaniam Mohan¹

Affiliations

¹ School of Chemical Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641046, India.
² DRDO-BU CLS, Bharathiar University, Coimbatore, Tamil Nadu 641046, India.
³ Department of Chemistry, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu 641114, India.

Abstract

New quinoline-based thiazole derivatives QPT and QBT were synthesized and characterized by various spectroscopic and single-crystal X-ray crystallographic studies. The metal-sensing properties of the probes were further examined by absorption and fluorescence spectrometry. The fluorescence intensity of QPT and QBT was remarkably quenched during the addition of Fe³⁺, Fe²⁺, and Cu²⁺ ions in THF/H₂O (1:1) at pH = 7.4 in HEPES buffer, while the addition of other metal ions did not affect the fluorescence intensity of the ligands. The detection ability of the probes QPT and QBT was further investigated by titration with various equivalents of metal ions, optimized pH ranges for detection, and reversibility with Na₂EDTA for biological applications.