Fluorescent antibiotics for real-time tracking of pathogenic bacteria

Lu Miao; Weiwei Liu; Qinglong Qiao; Xiaolian Li; Zhaochao Xu

doi:10.1016/j.jpha.2020.09.003

Fluorescent antibiotics for real-time tracking of pathogenic bacteria

J Pharm Anal. 2020 Oct;10(5):444-451. doi: 10.1016/j.jpha.2020.09.003. Epub 2020 Sep 18.

Authors

Lu Miao¹, Weiwei Liu^{1

2}, Qinglong Qiao¹, Xiaolian Li², Zhaochao Xu¹

Affiliations

¹ CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
² State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, China.

Abstract

The harm of pathogenic bacteria to humans has promoted extensive research on physiological processes of pathogens, such as the mechanism of bacterial infection, antibiotic mode of action, and bacterial antimicrobial resistance. Most of these processes can be better investigated by timely tracking of fluorophore-derived antibiotics in living cells. In this paper, we will review the recent development of fluorescent antibiotics featuring the conjugation with various fluorophores, and focus on their applications in fluorescent imaging and real-time detection for various physiological processes of bacteria in vivo.

Keywords: Fluorescent antibiotics; Fluorescent imaging; Fluorophore; Live-cell tracking; Pathogenic bacteria.

Publication types

Review