Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

Tian-Yi Shen; Wei-Nan Hu; Wen-Ting Cai; Hui-Zi Jin; Dong-Hui Yu; Jing-Hui Sun; Jing Yu

doi:10.1155/2020/3949735

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review

J Ophthalmol. 2020 Oct 9:2020:3949735. doi: 10.1155/2020/3949735. eCollection 2020.

Authors

Tian-Yi Shen^{1

2}, Wei-Nan Hu³, Wen-Ting Cai¹, Hui-Zi Jin¹, Dong-Hui Yu¹, Jing-Hui Sun², Jing Yu^{1

2}

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
² Ninghai First Hospital, Ninghai, Zhejiang 315600, China.
³ Anhui University of Science and Technology, Huainan, Anhui 232000, China.

Abstract

Purpose: To determine the effectiveness and safety of trabeculectomy along with amniotic membrane transplantation (AMT) for glaucoma.

Methods: This systematic review was performed using RevMan 5.3. We searched PubMed, EMBASE, and the Cochrane Library and included studies published until September 2019. The treatment group included patients with AMT and trabeculectomy (group A), and the control group had only trabeculectomy (group B). We only included randomized controlled trials. The outcomes were intraocular pressure (IOP), complete success rate, number of antiglaucoma medications, and complications.

Results: Five studies, including 174 eyes (87 eyes in the AMT group and 87 eyes in the control group), were eligible in this review. The parameters had no significant difference in heterogeneity between the AMT and control groups preoperatively. In the AMT group, the mean IOP was significantly lower at 3 and 12 months after operation (P < 0.0001 and P = 0.02, respectively), while the number of complete successes in the AMT group was significantly higher at 6 and 12 months (P = 0.02 and P = 0.003, respectively) compared with the control group. Complications, including a flat anterior chamber and hyphema, appeared to be decreased in the AMT group compared to the control group (P = 0.02 and P = 0.02, respectively). No differences were observed in the number of antiglaucoma medications, hypotony, encapsulated bleb, or choroidal detachment.

Conclusion: Compared with only trabeculectomy, it is more efficient and safer to add AMT to trabeculectomy during glaucoma filtering surgery.