Nanomolar level detection of non-steroidal antiandrogen drug flutamide based on ZnMn2O4 nanoparticles decorated porous reduced graphene oxide nanocomposite electrode

Krishnan Venkatesh; Balamurugan Muthukutty; Shen-Ming Chen; Chelladurai Karuppiah; Baishnisha Amanulla; Chun-Chen Yang; Sayee Kannan Ramaraj

doi:10.1016/j.jhazmat.2020.124096

Nanomolar level detection of non-steroidal antiandrogen drug flutamide based on ZnMn₂O₄ nanoparticles decorated porous reduced graphene oxide nanocomposite electrode

J Hazard Mater. 2021 Mar 5:405:124096. doi: 10.1016/j.jhazmat.2020.124096. Epub 2020 Oct 15.

Authors

Krishnan Venkatesh¹, Balamurugan Muthukutty², Shen-Ming Chen³, Chelladurai Karuppiah⁴, Baishnisha Amanulla¹, Chun-Chen Yang⁵, Sayee Kannan Ramaraj⁶

Affiliations

¹ PG and Research Department of Chemistry, Thiagarajar College, Madurai, Tamil Nadu, India.
² Electroanalysis and Biotelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.
³ Electroanalysis and Biotelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC. Electronic address: smchen78@ms15.hinet.net.
⁴ Battery Research center of Green Energy, Ming Chi University of technology, New Taipei City 24301, Taiwan, ROC. Electronic address: kcdurai.rmd@gmail.com.
⁵ Battery Research center of Green Energy, Ming Chi University of technology, New Taipei City 24301, Taiwan, ROC. Electronic address: ccyang@mail.mcut.edu.tw.
⁶ PG and Research Department of Chemistry, Thiagarajar College, Madurai, Tamil Nadu, India. Electronic address: sayeekannanramaraj@gmail.com.

PMID: 33131940
DOI: 10.1016/j.jhazmat.2020.124096

Abstract

Flutamide is a non-steroidal antiandrogen drug and widely used in the treatment of prostatic carcinoma. Nevertheless, the excessive intake and improper disposal could affect the living organisms. In this work, we have synthesized a new nanocomposite based on ZnMn₂O₄ nanoparticles and porous reduced graphene oxide nanosheets (ZnMn₂O₄-PGO) for the electrocatalytic detection of flutamide (FLU) drug. The crystallinity and morphological properties of ZnMn₂O₄-PGO composite examined by different characterization techniques such as X-ray diffraction, Raman spectroscopy and so on. The fabricated ZnMn₂O₄-PGO nanocomposite modified electrode exhibited superior electrocatalytic performance to FLU drug in an optimized pH electrolyte. Fascinatingly, the electrode received a wide linear range (0.05-3.5 µM) with limit of detection of 8 nM. Besides, the developed ZnMn₂O₄-PGO nanocomposite electrode showed good sensitivity 1.05 µAµM^-1 cm^-2 and excellent selectivity for FLU detection in presence of various interfering species. A developed disposable electrode was scrutinized to determine FLU level in human urine samples by spiking method and the results achieved good recoveries in real sample analysis.

MeSH terms

Androgen Antagonists
Electrochemical Techniques
Electrodes
Flutamide
Graphite*
Humans
Nanocomposites*
Nanoparticles*
Pharmaceutical Preparations*
Porosity

Substances

Androgen Antagonists
Pharmaceutical Preparations
graphene oxide
Flutamide
Graphite