Habitually inactive physically - a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

Katarzyna Micielska; Jakub Antoni Kortas; Anna Gmiat; Joanna Jaworska; Marta Kozlowska; Anna Lysak-Radomska; Ewa Rodziewicz-Flis; Malgorzata Zychowska; Ewa Ziemann

doi:10.1016/j.physbeh.2020.113235

Habitually inactive physically - a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

Physiol Behav. 2021 Feb 1:229:113235. doi: 10.1016/j.physbeh.2020.113235. Epub 2020 Oct 29.

Authors

Katarzyna Micielska¹, Jakub Antoni Kortas², Anna Gmiat³, Joanna Jaworska⁴, Marta Kozlowska³, Anna Lysak-Radomska⁵, Ewa Rodziewicz-Flis⁶, Malgorzata Zychowska⁷, Ewa Ziemann⁸

Affiliations

¹ Department of Physical Education and Lifelong Sports, Poznan University of Physical Education, Poznan 61-871, Poland; Department of Anatomy and Anthropology, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
² Department of Sport, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
³ Department of Physiology, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
⁴ Department of Physical Education and Lifelong Sports, Poznan University of Physical Education, Poznan 61-871, Poland.
⁵ Department of Occupation Therapy, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
⁶ Department of Physiotherapy, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
⁷ Institute of Physical Education, Department of Sport, Kazimierz Wielki University in Bydgoszcz, Bydgoszcz 85-064, Poland.
⁸ Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan 61-871, Poland. Electronic address: ziemann@awf.poznan.pl.

PMID: 33130034
DOI: 10.1016/j.physbeh.2020.113235

Abstract

This study verified the impact of five weeks of high-intensity circuit training (HICT) on changes in concentration of exerkines in relation to cognitive functions. Sedentary women (n = 33; age=39±13 years) were randomly assigned into the HICT (n = 21) group or the control group (n = 12). The HICT group performed 15 training sessions; meanwhile, the control group performed the HICT twice, only at baseline and at the end of the experiment. Blood samples were collected before, 1 h and 24 h after the first and last HICT, to evaluate the concentration of exerkines: brain-derived neurotrophic factor (BDNF), irisin, fibroblast growth factor-21 (FGF-21), interleukin-6 (IL-6) and cathepsin B (CATB) using enzyme immunoassay method. Cognitive functions and quality of life were assessed using the Vienna Test System and the Short Form Health Survey. HICT induced improvement of cognitive function and quality of life, and these changes were accompanied by an increase of BDNF and shifts in CATB concentration. HICT program caused a decrease in FGF-21 concentration, which was modified by age and insulin sensitivity. The improvement of cognitive functions was more pronounced in females, who experienced a drop in FGF-21. In summary, HICT program, that can be performed during pandemic, enhanced cognitive functions and this response was related to changes in exerkines.

Keywords: brain-derived neurotrophic factor; cathepsin B; fibroblast growth factor-21; inter-individual variability; irisin.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain-Derived Neurotrophic Factor
Circuit-Based Exercise*
Cognitive Dysfunction*
Female
Humans
Insulin
Insulin Resistance*
Middle Aged
Quality of Life

Substances

Brain-Derived Neurotrophic Factor
Insulin