Structured histopathology for endotyping and planning rational treatment in chronic rhinosinusitis

Giuseppe Brescia; Lara Alessandrini; Gino Marioni

doi:10.1016/j.amjoto.2020.102795

Structured histopathology for endotyping and planning rational treatment in chronic rhinosinusitis

Am J Otolaryngol. 2021 Jan-Feb;42(1):102795. doi: 10.1016/j.amjoto.2020.102795. Epub 2020 Oct 24.

Authors

Giuseppe Brescia¹, Lara Alessandrini², Gino Marioni³

Affiliations

¹ Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy.
² Department of Medicine DIMED, Padova University, Padova, Italy.
³ Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy. Electronic address: gino.marioni@unipd.it.

PMID: 33128996
DOI: 10.1016/j.amjoto.2020.102795

Abstract

In chronic rhinosinusitis (CRS), endotyping, being based on the pathogenic mechanism, provides a precise picture appropriate for use in clinical practice. Structured histopathological examination of CRS is considered a necessary step in efforts to establish its pathogenesis and improve our endotyping capabilities. Herein we discuss the associations between histopathology and clinical characteristics of CRS patients to assist medical and surgical treatment choices.

Keywords: Biologics; Chronic rhinosinusitis; Endotypes; Nasal polyps; Structured histopathology.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Antibodies, Monoclonal / therapeutic use
Asthma
Chronic Disease
Endoscopy / methods
Eosinophils / pathology
Humans
Hypersensitivity
Inflammation
Nasal Mucosa / pathology
Nasal Polyps / diagnosis
Nasal Polyps / drug therapy
Nasal Polyps / pathology
Nasal Polyps / surgery
Nasal Surgical Procedures / methods
Patient Care Planning*
Rhinitis / diagnosis
Rhinitis / drug therapy
Rhinitis / pathology*
Rhinitis / surgery*
Sinusitis / diagnosis
Sinusitis / drug therapy
Sinusitis / pathology*
Sinusitis / surgery*

Substances

Adrenal Cortex Hormones
Antibodies, Monoclonal