Hydrazine exposure: A near-infrared ICT-based fluorescent probe and its application in bioimaging and sewage analysis

Meiqing Zhu; Zongyuan Zhao; Yan Huang; Fugang Fan; Fu Wang; Weilun Li; Xiangwei Wu; Rimao Hua; Yi Wang

doi:10.1016/j.scitotenv.2020.143102

Hydrazine exposure: A near-infrared ICT-based fluorescent probe and its application in bioimaging and sewage analysis

Sci Total Environ. 2021 Mar 10:759:143102. doi: 10.1016/j.scitotenv.2020.143102. Epub 2020 Oct 16.

Authors

Meiqing Zhu¹, Zongyuan Zhao¹, Yan Huang¹, Fugang Fan¹, Fu Wang², Weilun Li², Xiangwei Wu¹, Rimao Hua³, Yi Wang⁴

Affiliations

¹ Key Laboratory of Agri-food Safety of Anhui Province, School of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei 230036, China.
² Inner Mongolia Emissions Trading Management Center, No. 39, Tengfei Road, Hohhot 010011, China.
³ Key Laboratory of Agri-food Safety of Anhui Province, School of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei 230036, China. Electronic address: rimaohua@ahau.edu.cn.
⁴ Key Laboratory of Agri-food Safety of Anhui Province, School of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei 230036, China; Department of Entomology and Nematology and UCD Comprehensive Cancer Center, University of California, Davis, CA 95616, USA. Electronic address: wangyi1987@cau.edu.cn.

PMID: 33127121
DOI: 10.1016/j.scitotenv.2020.143102

Abstract

Hydrazine (N₂H₄) is an environment pollutant with high acute toxicity and potential carcinogenicity, and detection of N₂H₄ has attracted increasing attention. In the present study, a low toxicity near-infrared fluorescent probe (DCDB) based on the intramolecular charge transfer (ICT) principle was developed. The probe DCDB exhibits excellent selectivity and high sensitivity (LOD = 1.27 ppb) for N₂H₄, fast reaction rate (5 min), extremely large Stokes shift (160 nm). The color transformation of the DCDB-N₂H₄ system from purple to pink can be observed with the naked eye. The success of N₂H₄ test strips to detect trace N₂H₄ in actual sewage strongly illustrates the practical application potential of DCDB. Importantly, DCDB can be utilized to monitor the distribution of exogenous N₂H₄ in vivo and in vitro.

Keywords: Density functional theory; Fluorescent probe; N(2)H(4); Near-infrared; Samples analysis.

MeSH terms

Fluorescent Dyes*
Hydrazines
Sewage*
Spectrometry, Fluorescence

Substances

Fluorescent Dyes
Hydrazines
Sewage