The transcriptomic signature of the aging podocyte

Dhanunjay Mukhi; Katalin Susztak

doi:10.1016/j.kint.2020.08.004

The transcriptomic signature of the aging podocyte

Kidney Int. 2020 Nov;98(5):1079-1081. doi: 10.1016/j.kint.2020.08.004.

Authors

Dhanunjay Mukhi¹, Katalin Susztak²

Affiliations

¹ Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
² Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Institute of Diabetes Obesity and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: ksusztak@pennmedicine.upenn.edu.

Abstract

Aging is the strongest independent risk factor for chronic kidney disease. Glomerular epithelial cells are unable to proliferate and have limited ability to renew; therefore, podocytes must maintain a delicate intracellular homeostasis that enables them to function and adapt to stress endured during the human life span. Here, Wang et al. performed unbiased transcriptomic analysis of aging podocytes and identified important novel regulators.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aging / genetics
Animals
Humans
Kidney Diseases*
Kidney Glomerulus
Mice
Podocytes*
Transcriptome

Abstract

Publication types

MeSH terms

Grants and funding