When Gut Microbiota Creep into Fat, the Fat Creeps Back

Sean P Spencer; Justin L Sonnenburg

doi:10.1016/j.cell.2020.10.008

When Gut Microbiota Creep into Fat, the Fat Creeps Back

Cell. 2020 Oct 29;183(3):589-591. doi: 10.1016/j.cell.2020.10.008.

Authors

Sean P Spencer¹, Justin L Sonnenburg²

Affiliations

¹ Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, CA, USA; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA. Electronic address: seanspen@stanford.edu.
² Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA; Center for Human Microbiome Studies, Stanford School of Medicine, Stanford, CA, USA. Electronic address: jsonnenburg@stanford.edu.

Abstract

Ha and colleagues describe a previously unappreciated diversity of microbes in the mesenteric adipose tissue (MAT) surrounding the GI tract. Viable bacteria that are mislocalized from the gut microbiota and metabolically adapted to the MAT contribute to the "creeping fat" of Crohn's disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adaptation, Physiological
Adipose Tissue
Crohn Disease*
Gastrointestinal Microbiome*
Humans
Mesentery

Abstract

Publication types

MeSH terms

Grants and funding