Prevalence of the prothrombin G20210A mutation among ischemic stroke patients

Salar A Ahmed; Sazgar A Hameed; Bashdar M Hussen; Abbas Salihi

doi:10.34172/jcvtr.2020.39

Prevalence of the prothrombin G20210A mutation among ischemic stroke patients

J Cardiovasc Thorac Res. 2020;12(3):227-230. doi: 10.34172/jcvtr.2020.39. Epub 2020 Sep 3.

Authors

Salar A Ahmed¹, Sazgar A Hameed², Bashdar M Hussen³, Abbas Salihi^{4

5}

Affiliations

¹ Department of Clinical Biochemistry, College of Medicine, Hawler Medical University, Erbil, Iraq.
² Central laboratory, Hawler Teaching Hospital, Erbil, Iraq.
³ Department of Pharmacognocy, College of Pharmacy, Hawler Medical University, Iraq.
⁴ Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Iraq.
⁵ Department of Medical Analysis, Faculty of Science, Tishk International University, Erbil, Iraq.

Abstract

Introduction: Ischemic stroke is characterized as a sudden neurological deficit attributed to an acute focal injury of the central nervous system by a vascular cause. This study was performed to determine the frequency of G20210A mutation in the prothrombin gene and its effectiveness on the incidence of ischemic stroke in the Erbil city of Kurdistan region, Iraq. Methods: A total of 50 patients with ischemic stroke was analyzed for the detection of prothrombin gene mutation (G20210A), using polymerase chain reaction (PCR), Restriction fragment length polymorphism (RFLP) with Hind III restriction enzyme. Results: We observed no evidence of an association between ischemic stroke and G20210A mutation in the prothrombin gene in this region. Conclusion: Our finding demonstrates that prothrombotic gene variant seems not to be linked to the incidence of ischemic stroke in Erbil region.

Keywords: Ischemic Stroke; Prothrombin Gene Mutation; Venous Thrombosis.