Assessing Severity of Disease in Patients with Ulcerative Colitis

Baldeep Singh Pabla; David Allen Schwartz

doi:10.1016/j.gtc.2020.08.003

Assessing Severity of Disease in Patients with Ulcerative Colitis

Gastroenterol Clin North Am. 2020 Dec;49(4):671-688. doi: 10.1016/j.gtc.2020.08.003. Epub 2020 Sep 23.

Authors

Baldeep Singh Pabla¹, David Allen Schwartz²

Affiliations

¹ Department of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Suite 220, 1211 21st Avenue South, Nashville, TN 37232-5280, USA. Electronic address: baldeep.pabla@vumc.org.
² Department of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Suite 220, 1211 21st Avenue South, Nashville, TN 37232-5280, USA. Electronic address: https://twitter.com/ibddoc09.

Abstract

Ulcerative colitis (UC) is a chronic disease that can present at various stages of disease activity and severity. Traditionally, severity scoring has focused on disease activity during a single moment with various tools, including patient-reported symptoms, as well as clinical, laboratory-based, endoscopic, histologic, and imaging variables. Optimal delivery of care depends on the accurate assessment of disease severity, which must take longitudinal variables into account. This article reviews the history of severity scoring in UC and provides a concise, clinically oriented approach to assessing disease severity.

Keywords: CRP; Clostridium difficile; Mayo score; PRO; Truelove and Witts; UCEIS.

Publication types

Review

MeSH terms

Colectomy
Colitis, Ulcerative / classification
Colitis, Ulcerative / diagnosis*
Colitis, Ulcerative / pathology
Colitis, Ulcerative / surgery
Endoscopy, Gastrointestinal / methods*
Evidence-Based Practice
Forecasting
Humans
Research Design*
Severity of Illness Index
Treatment Outcome