5-Methyltetrahydrohomofolate

Invest New Drugs. 1987;5(3):215-8. doi: 10.1007/BF00175290.

Abstract

5-methyltetrahydrohomofolate was developed in the 1970's as an antifolate with the potential to overcome methotrexate resistance. This review summarizes the preclinical and clinical data which have accumulated to date. It is concluded that more recent, better characterized antifolates offer greater potential in achieving the goals for which this drug was introduced.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Drug Evaluation
  • Folic Acid / analogs & derivatives*
  • Folic Acid / pharmacokinetics
  • Folic Acid / therapeutic use
  • Folic Acid Antagonists / pharmacokinetics
  • Folic Acid Antagonists / pharmacology
  • Folic Acid Antagonists / therapeutic use*
  • Humans

Substances

  • Antimetabolites, Antineoplastic
  • Folic Acid Antagonists
  • 5-methyltetrahydrohomofolic acid
  • Folic Acid