Qualitative theoretical modeling to study the possibility of detecting multi-virus in blood flow using Nano-quartz crystal microbalance

Math Biosci Eng. 2020 Jun 29;17(5):4563-4577. doi: 10.3934/mbe.2020252.

Abstract

Methods for testing the presence of a virus in the blood are of interest to researchers and doctors because they determine how rapidly a virus is detected. In general, virus detection is a major scientific problem due to the serious effects of viruses on the human body. At present, only one virus can be detected in a single test. This potentially costs the medical establishment more time and money that could be saved if blood testing was more efficient. This study presents a qualitative method to enable doctors and researchers to detect more than one virus simultaneously. This was performed using quartz nanoparticles. Using polymer thin films of polydimethylsiloxane (PDMS), each chip emits a different frequency for each specific type of virus on the chip. The multiplicity of these chips allows for the detection of a number of viruses with the same number of nanoscale chips simultaneously. Blood flow around quartz nanoparticles was modelled. In this model, several conventional Quartz Crystal Microbalance (QCM) with nanostructures (Nano-QCM) particles are inserted into the three main types of blood vessels. The results showed that the best location for the Nano-QCM is the large artery and that it is possible to test for a number of viruses in all types of blood vessels.

Keywords: blood flow; heat transfer; laminar stream; quartz nanoparticles; virus detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques*
  • Humans
  • Nanostructures*
  • Quartz
  • Quartz Crystal Microbalance Techniques
  • Viruses*

Substances

  • Quartz