Metal-Free Intramolecular Aminophosphination of Allenes

Zhantao Yang; Zhenzhen Sun; Ningning Zhu; Wenyan Li; Meng Han; Yan Qiao; Chun-Hua Yang; Junbiao Chang

doi:10.1021/acs.joc.0c02169

Metal-Free Intramolecular Aminophosphination of Allenes

J Org Chem. 2020 Dec 4;85(23):15686-15692. doi: 10.1021/acs.joc.0c02169. Epub 2020 Oct 29.

Authors

Zhantao Yang^{1

2}, Zhenzhen Sun¹, Ningning Zhu¹, Wenyan Li¹, Meng Han¹, Yan Qiao³, Chun-Hua Yang¹, Junbiao Chang²

Affiliations

¹ Henan Province Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, 436 Xian'ge Road, Anyang 455000, People's Republic of China.
² School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, People's Republic of China.
³ School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan 450001, People's Republic of China.

PMID: 33119301
DOI: 10.1021/acs.joc.0c02169

Abstract

A metal-free intramolecular aminophosphination of sulfonamidoallenes with diarylphosphine oxides and Tf₂O was developed. This method offers a general and practical procedure to construct valuable alkenylphosphine-substituted N-heterocycles via the bifunctionalization reaction of allenes in good yields under mild conditions.