Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan; Moustapha Kassem; Robert J Pignolo; Gustavo Duque

doi:10.1002/jbmr.4204

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

J Bone Miner Res. 2021 Jan;36(1):12-23. doi: 10.1002/jbmr.4204. Epub 2020 Nov 12.

Authors

Jack Feehan^{1

2}, Moustapha Kassem^{3

4}, Robert J Pignolo⁵, Gustavo Duque^{1

2}

Affiliations

¹ Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia.
² Department of Medicine, University of Melbourne-Western Health, Melbourne, VIC, Australia.
³ Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark, Odense, Denmark.
⁴ Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.
⁵ Department of Medicine, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, USA.

PMID: 33118647
DOI: 10.1002/jbmr.4204

Abstract

Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).

Keywords: CIRCULATING OSTEOGENIC PRECURSOR CELLS; COP CELLS; FRACTURE; FRAILTY; HETEROTOPIC OSSIFICATION; OSTEOPOROSIS; VASCULAR CALCIFICATION.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone and Bones
Cell Differentiation
Osteogenesis*
Stem Cells*