Ultrasound-guided radiofrequency ablation is an effective and safe treatment option for solid and cystic, cold, benign symptomatic thyroid nodules of ≥ 2 cm and less-than 20 ml. It is non-invasive, and in this review, we consider it well supported in the current literature for its efficacy, safety, patient satisfaction and cost. In addition, it is also a promising alternative therapy for hyperfunctioning nodules.