Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro

Adelya A Galiakberova; Erdem B Dashinimaev

doi:10.3389/fcell.2020.00815

Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro

Front Cell Dev Biol. 2020 Oct 8:8:815. doi: 10.3389/fcell.2020.00815. eCollection 2020.

Authors

Adelya A Galiakberova^{1

2}, Erdem B Dashinimaev^{2

3}

Affiliations

¹ Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
² Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.
³ Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia.

Abstract

Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems. Such cells also have an application in regenerative medicine. The most convenient and acceptable source of NSCs is pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells). However, there are many different protocols for the induction and differentiation of NSCs, and these result in a wide range of neural cell types. This review is intended to summarize the knowledge accumulated, to date, by workers in this field. It should be particularly useful for researchers who are beginning investigations in this area of cell biology.

Keywords: ESC; NSC; iPSC; neural stem cells; neurogenesis; pluripotent stem cells; regenerative medicine.

Publication types

Review