Emerging Landscapes of Tumor Immunity and Metabolism

Fan Wu; Ye Cheng; Liangliang Wu; Wenling Zhang; Wubing Zheng; Qian Wang; Hongyong Cao; Xiongxiong Pan; Weiwei Tang

doi:10.3389/fonc.2020.575037

Emerging Landscapes of Tumor Immunity and Metabolism

Front Oncol. 2020 Oct 7:10:575037. doi: 10.3389/fonc.2020.575037. eCollection 2020.

Authors

Fan Wu¹, Ye Cheng¹, Liangliang Wu¹, Wenling Zhang², Wubing Zheng¹, Qian Wang³, Hongyong Cao¹, Xiongxiong Pan⁴, Weiwei Tang¹

Affiliations

¹ Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
² Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
³ Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
⁴ Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Abstract

The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.

Keywords: cancer; drug resistance; immunity; metabolism; reprogram.

Publication types

Review