Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

Cells. 2020 Oct 25;9(11):2352. doi: 10.3390/cells9112352.

Abstract

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.

Keywords: cholesterol synthesis; farnesyl-diphosphate farnesyltransferase 1; lipid rafts; prognostic marker; tumour progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cholesterol / metabolism
  • Disease Susceptibility*
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors
  • Farnesyl-Diphosphate Farnesyltransferase / genetics*
  • Farnesyl-Diphosphate Farnesyltransferase / metabolism
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / etiology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Structure-Activity Relationship
  • Tumor Microenvironment* / drug effects
  • Tumor Microenvironment* / genetics

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Cholesterol
  • Farnesyl-Diphosphate Farnesyltransferase