Totally implantable enzymatic biofuel cell and brain stimulator operating in bird through wireless communication

Dahye Lee; Sung Hee Jeong; Seunghyeon Yun; Sunhyo Kim; Jaehoon Sung; Jungmin Seo; Suyeon Son; Ji Tae Kim; Lina Susanti; Youngseok Jeong; Sanghyun Park; Kangmoon Seo; Sung June Kim; Taek Dong Chung

doi:10.1016/j.bios.2020.112746

Totally implantable enzymatic biofuel cell and brain stimulator operating in bird through wireless communication

Biosens Bioelectron. 2021 Jan 1:171:112746. doi: 10.1016/j.bios.2020.112746. Epub 2020 Oct 20.

Authors

Dahye Lee¹, Sung Hee Jeong², Seunghyeon Yun³, Sunhyo Kim⁴, Jaehoon Sung⁵, Jungmin Seo³, Suyeon Son¹, Ji Tae Kim¹, Lina Susanti⁴, Youngseok Jeong⁴, Sanghyun Park⁴, Kangmoon Seo⁴, Sung June Kim³, Taek Dong Chung⁶

Affiliations

¹ Department of Chemistry, Seoul National University, 08826, Seoul, Republic of Korea.
² Graduate School of Convergence Science and Technology, Seoul National University, 16229, Suwon-si, Gyeonggi-do, Republic of Korea.
³ Department of Electrical and Computer Engineering, Seoul National University, 08826, Seoul, Republic of Korea.
⁴ Department of Veterinary Clinical Sciences, Seoul National University, 08826, Seoul, Republic of Korea.
⁵ Department of Electrical and Computer Engineering, Seoul National University, 08826, Seoul, Republic of Korea; Pratt School of Engineering, Duke University, Durham, NC, 27708, USA.
⁶ Department of Chemistry, Seoul National University, 08826, Seoul, Republic of Korea; Graduate School of Convergence Science and Technology, Seoul National University, 16229, Suwon-si, Gyeonggi-do, Republic of Korea; Electrochemistry Laboratory, Advanced Institutes of Convergence Technology, 16229, Suwon-Si, Gyeonggi-do, Republic of Korea. Electronic address: tdchung@snu.ac.kr.

PMID: 33113388
DOI: 10.1016/j.bios.2020.112746

Abstract

Animals digest food to fuel brain neurometabolism via cellular respiration. This study demonstrates the combination of a biofuel cell (BFC) and an animal brain stimulator (ABS) implanted in a pigeon. Glucose oxidation and oxygen reduction in an enzymatic BFC supplied electrical power to the ABS. Power from the BFC reached 0.12 mW in vitro and 0.08 mW in vivo using only the natural glucose and oxygen in the pigeon's body. A power management integrated circuit is used to harvest energy from the in vivo BFC at a rate of 28.4 mJ over 10 min, which is sufficient for intermittent neurostimulation.

Keywords: Animal brain stimulator; Birds; Implantable biofuel cell; In vivo; Neurostimulation.

MeSH terms

Animals
Bioelectric Energy Sources*
Biosensing Techniques*
Birds
Brain
Communication
Electrodes
Glucose
Oxygen

Substances

Glucose
Oxygen