Effectiveness and Safety of Anti-interleukin-17 Therapies in Elderly Patients with Psoriasis

Acta Derm Venereol. 2020 Nov 4;100(18):adv00316. doi: 10.2340/00015555-3678.

Abstract

Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.

Keywords: anti-interleukin 17; drug survival; elderly; safety; psoriasis.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Antibodies, Monoclonal* / adverse effects
  • Humans
  • Immunotherapy
  • Psoriasis* / diagnosis
  • Psoriasis* / drug therapy
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal