Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome

Gavin Tjin; Louise E Purton

doi:10.1016/j.devcel.2020.09.026

Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome

Dev Cell. 2020 Oct 26;55(2):109-111. doi: 10.1016/j.devcel.2020.09.026.

Authors

Gavin Tjin¹, Louise E Purton²

Affiliations

¹ Stem Cell Regulation Unit, St. Vincent's Institute, Fitzroy, VIC 3065, Australia.
² Stem Cell Regulation Unit, St. Vincent's Institute, Fitzroy, VIC 3065, Australia; The University of Melbourne Department of Medicine at St. Vincent's Hospital, Fitzroy, VIC 3065, Australia. Electronic address: lpurton@svi.edu.au.

PMID: 33108749
DOI: 10.1016/j.devcel.2020.09.026

Abstract

The generation of adult hematopoietic stem and progenitor cells (HSPCs) from embryonic and induced pluripotent stem cells (iPSCs) will provide therapeutic benefits but is currently elusive. In this issue of Developmental Cell, Frame et al. reveal that the inflammasome has a key role in HSPCs specification during endothelial-to-hematopoietic transition (EHT).

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Comment

MeSH terms

Blood Cells
Cell Differentiation
Hematopoiesis
Hematopoietic Stem Cell Transplantation*
Inflammasomes*
Sugars

Substances

Inflammasomes
Sugars