Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities

Nat Prod Res. 2022 Apr;36(8):1927-1933. doi: 10.1080/14786419.2020.1837816. Epub 2020 Oct 27.

Abstract

A new diarylheptanoid, (1 R,2S,3S,5S)-2,3-dihydroxy-3',3''-dimethoxy-4'-de-O-methylcentrolobine (1) and a new bisabolane-type sesquiterpenoid, (1 R,7S)-1,12,13-trihydroxybisabola-3,10-diene (2), together with nineteen known compounds (3-21) were isolated from the EtOH extract of the stems and branches of Viscum coloratum (Kom.) Nakai. Their structures were elucidated by extensive analysis of 1 D and 2 D NMR spectra and from the HRESIMS. All the compounds were evaluated for their cytotoxic activity against eight human tumor cell lines.

Keywords: Santalaceae; Viscum coloratum; cytotoxic activity; diarylheptanoid; sesquiterpenoid.

MeSH terms

  • Antineoplastic Agents*
  • Diarylheptanoids
  • Humans
  • Magnetic Resonance Spectroscopy
  • Viscum* / chemistry

Substances

  • Antineoplastic Agents
  • Diarylheptanoids