Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

Weihao Chen; Chunmei Chen; Jieyi Long; Sujuan Lan; Xiuping Lin; Shengrong Liao; Bin Yang; Xuefeng Zhou; Junfeng Wang; Yonghong Liu

doi:10.1038/s41429-020-00378-y

Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

J Antibiot (Tokyo). 2021 Feb;74(2):156-159. doi: 10.1038/s41429-020-00378-y. Epub 2020 Oct 27.

Authors

Weihao Chen^{1

2}, Chunmei Chen^{1

2}, Jieyi Long^{1

2}, Sujuan Lan³, Xiuping Lin^{1

4}, Shengrong Liao^{1

4}, Bin Yang^{1

4}, Xuefeng Zhou^{1

4}, Junfeng Wang^{5

6}, Yonghong Liu^{7

8

9}

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.
² University of Chinese Academy of Sciences, 19 Yuquan Road, 100049, Beijing, China.
³ Guangdong Pharmaceutical University, Guangzhou, 510006, China.
⁴ Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.
⁵ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. wangjunfeng@scsio.ac.cn.
⁶ Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. wangjunfeng@scsio.ac.cn.
⁷ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. yonghongliu@scsio.ac.cn.
⁸ University of Chinese Academy of Sciences, 19 Yuquan Road, 100049, Beijing, China. yonghongliu@scsio.ac.cn.
⁹ Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. yonghongliu@scsio.ac.cn.

PMID: 33106626
DOI: 10.1038/s41429-020-00378-y

Abstract

Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC₅₀ values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml^-1, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Aspergillus / chemistry
Aspergillus / metabolism*
Fermentation
Glucosidases / drug effects
Magnetic Resonance Spectroscopy
Methionine / analogs & derivatives
Microbial Sensitivity Tests
Molecular Structure
Oligopeptides
Optical Rotation
Pteridines
Sesquiterpenes
Spectrometry, Mass, Electrospray Ionization
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Oligopeptides
Pteridines
Sesquiterpenes
penilumamide
Methionine
Glucosidases