Bayesian variable selection in linear quantile mixed models for longitudinal data with application to macular degeneration

PLoS One. 2020 Oct 26;15(10):e0241197. doi: 10.1371/journal.pone.0241197. eCollection 2020.

Abstract

This paper presents a Bayesian analysis of linear mixed models for quantile regression based on a Cholesky decomposition for the covariance matrix of random effects. We develop a Bayesian shrinkage approach to quantile mixed regression models using a Bayesian adaptive lasso and an extended Bayesian adaptive group lasso. We also consider variable selection procedures for both fixed and random effects in a linear quantile mixed model via the Bayesian adaptive lasso and extended Bayesian adaptive group lasso with spike and slab priors. To improve mixing of the Markov chains, a simple and efficient partially collapsed Gibbs sampling algorithm is developed for posterior inference. Simulation experiments and an application to the Age-Related Macular Degeneration Trial data to demonstrate the proposed methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • Computer Simulation*
  • Datasets as Topic
  • Humans
  • Linear Models*
  • Longitudinal Studies
  • Macular Degeneration*

Grants and funding

The second author was supported by the Fundamental Research Funds for the Central Universities (Grant No.3122014K013).