Chimeric Antigen Receptor T-Cell Therapy-Associated Cardiomyopathy in Patients With Refractory or Relapsed Non-Hodgkin Lymphoma

Sarju Ganatra; Robert Redd; Salim S Hayek; Rohan Parikh; Tariq Azam; Gregory A Yanik; Lauren Spendley; Sarah Nikiforow; Caron Jacobson; Anju Nohria

doi:10.1161/CIRCULATIONAHA.120.048100

Chimeric Antigen Receptor T-Cell Therapy-Associated Cardiomyopathy in Patients With Refractory or Relapsed Non-Hodgkin Lymphoma

Circulation. 2020 Oct 27;142(17):1687-1690. doi: 10.1161/CIRCULATIONAHA.120.048100. Epub 2020 Oct 26.

Authors

Sarju Ganatra^{1

2

3}, Robert Redd⁴, Salim S Hayek⁵, Rohan Parikh¹, Tariq Azam⁵, Gregory A Yanik⁶, Lauren Spendley⁷, Sarah Nikiforow⁷, Caron Jacobson⁷, Anju Nohria^{2

3}

Affiliations

¹ Cardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Burlington, MA (S.G., R.P.).
² Adult Cancer Survivorship Program (S.G., A.N.), Dana Farber Cancer Institute, Boston, MA.
³ Cardio-Oncology Program, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (S.G., A.N.).
⁴ Department of Data Science (R.R.), Dana Farber Cancer Institute, Boston, MA.
⁵ Division of Cardiology (S.S.H., T.A.), University of Michigan, Ann Arbor.
⁶ Division of Hematology-Oncology (G.A.Y.), University of Michigan, Ann Arbor.
⁷ Division of Hematology-Oncology (L.S., S.N., C.J.), Dana Farber Cancer Institute, Boston, MA.

PMID: 33104402
DOI: 10.1161/CIRCULATIONAHA.120.048100

No abstract available

Keywords: axicabtagene ciloleucel; cardiomyopathy; cardiotoxicity; chimeric antigen receptor T-cell therapy; cytokine release syndrome; heart failure; lymphoma, non-Hodgkin; receptors, chimeric antigen; tisagenlecleucel.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Cardiomyopathies / drug therapy*
Cell- and Tissue-Based Therapy / methods*
Humans
Lymphoma, Non-Hodgkin / drug therapy*
Middle Aged
Receptors, Chimeric Antigen / therapeutic use*
Retrospective Studies
Young Adult

Substances

Receptors, Chimeric Antigen