An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Cijun Shuai; Wang Guo; Chengde Gao; Youwen Yang; Ping Wu; Pei Feng

doi:10.18063/IJB.v4i1.120

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Int J Bioprint. 2017 Nov 1;4(1):120. doi: 10.18063/IJB.v4i1.120. eCollection 2018.

Authors

Cijun Shuai^{1

2

3}, Wang Guo¹, Chengde Gao¹, Youwen Yang¹, Ping Wu⁴, Pei Feng¹

Affiliations

¹ State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, China.
² Jiangxi University of Science and Technology, Ganzhou, China.
³ Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
⁴ College of Chemistry, Xiangtan University, Xiangtan, China.

Abstract

Bone repair failure caused by implant-related infections is a common and troublesome problem. In this study, an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide (nMgO) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The results indicated the scaffold exerted high antibacterial activity. The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species (ROS) and direct contact action, respectively, which resulted in the damage of their structures and functions. Besides, nMgO significantly increased the compressive properties of the scaffold including strength and modulus, due to its excellent mechanical properties and uniform dispersion in the PHBV matrix. Moreover, the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold. The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation, as well as osteogenic differentiation. The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering.

Keywords: Nano magnesium oxide; antibacterial scaffolds; cytocompatibility; degradation properties; mechanical properties.