Screening for Cervical Cancer

Med Clin North Am. 2020 Nov;104(6):1063-1078. doi: 10.1016/j.mcna.2020.08.006.

Abstract

The most effective strategy for cervical cancer prevention involves vaccination to prevent human papillomavirus (HPV) infections during adolescence followed by screening to detect HPV infections during adulthood. HPV vaccination before sexual debut can prevent HPV infections, precancers, and cancers. HPV vaccination of sexually active populations does not prevent cancer. Screening with HPV testing is the most effective method of detecting precancers and cancers between ages 25 and 65. Ensuring adequate screening around the age of menopause may be the key to preventing cervical cancer among elderly women. Most cervical cancers at all ages occur among unscreened or underscreened women.

Keywords: Cervical cancer screening; Cervical cytology; HPV test; PAP test.

Publication types

  • Review

MeSH terms

  • Early Detection of Cancer
  • Female
  • Humans
  • Papanicolaou Test
  • Papillomaviridae / immunology
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / prevention & control
  • Primary Health Care
  • United States
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / prevention & control*
  • Vaccination