Alopecia Areata: A Complex Cytokine Driven Disease

J Investig Dermatol Symp Proc. 2020 Nov;20(1):S55-S57. doi: 10.1016/j.jisp.2020.04.007.

Abstract

Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alopecia Areata / drug therapy
  • Alopecia Areata / genetics
  • Alopecia Areata / immunology
  • Alopecia Areata / metabolism*
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism*
  • Cytokines / genetics
  • Cytokines / metabolism*
  • Gene Expression
  • Humans
  • Keratins / genetics
  • Molecular Targeted Therapy
  • Transcriptome

Substances

  • Cytokines
  • Keratins