Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

Kun-Ying Lu; Pei-Ru Jheng; Long-Sheng Lu; Lekshmi Rethi; Fwu-Long Mi; Er-Yuan Chuang

doi:10.1016/j.ijbiomac.2020.10.091

Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

Int J Biol Macromol. 2021 Jan 1:166:98-107. doi: 10.1016/j.ijbiomac.2020.10.091. Epub 2020 Oct 20.

Authors

Kun-Ying Lu¹, Pei-Ru Jheng², Long-Sheng Lu³, Lekshmi Rethi⁴, Fwu-Long Mi⁵, Er-Yuan Chuang⁶

Affiliations

¹ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; Department of Biochemistry and Molecular Cell Biology, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
² Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC.
³ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ROC.
⁴ International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC.
⁵ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; Department of Biochemistry and Molecular Cell Biology, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address: flmi530326@tmu.edu.tw.
⁶ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ROC; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital,111, Sec.3, Xinglong Road, Wenshan District, Taipei 116, Taiwan, ROC. Electronic address: eychuang@tmu.edu.tw.

PMID: 33091478
DOI: 10.1016/j.ijbiomac.2020.10.091

Abstract

Nanomaterial mediated cancer/tumor photo driven hyperthermia has obtained great awareness. Nevertheless, it is a challenge for improving the hyperthermic efficacy lacking resistance to stimulated thermal stress. We thus developed a bioinspired nano-platform utilizing inclusion complexation between photosensitive polypyrrole (Ppy) nanoparticles (NP) and fucoidan (FU). This FU-Ppy NP proved to be an excellent P-selectin-mediated, lung cancer-cell/tumor targeting delivery and specific accumulation, could augment cancer/tumor oxidative stress levels through producing cellular reactive oxygen species. Potent ROS/photothermal combinational therapeutic effects were exhibited by the bioinspired FU-Ppy NP through a selective P-selectin cancer/tumor targeting aptitude for the lung cancer cells/tumor compared with other nano-formulations. The usage of FU-Ppy NP also involves the potential mechanism of suppressing the biological expression of tumor vascular endothelial growth factor (VEGF). This FU biological macromolecule-amplified photothermally therapeutic nano-platform has promising potential for future medical translation in eradicating numerous tumors.

Keywords: Anticancer; Fucoidan polypyrrole nanoparticles; ROS boosted photothermal therapy; Vascular endothelial growth factor; p-Selectin mediated cancer delivery.

MeSH terms

Animals
Cell Line, Tumor
Humans
Light
Lung Neoplasms / metabolism
Lung Neoplasms / therapy*
Mice
Mice, Nude
Nanoparticles / chemistry*
Nanoparticles / radiation effects
Nanoparticles / therapeutic use
P-Selectin / metabolism
Photothermal Therapy / methods*
Polymers / chemistry*
Polysaccharides / chemistry*
Pyrroles / chemistry*
Reactive Oxygen Species / metabolism*
Vascular Endothelial Growth Factor A / metabolism

Substances

P-Selectin
Polymers
Polysaccharides
Pyrroles
Reactive Oxygen Species
Vascular Endothelial Growth Factor A
polypyrrole
fucoidan