Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases

Lu Yang; Weihua Tan; Xinzhi Yang; Yong You; Jing Wang; Gebo Wen; Jing Zhong

doi:10.1002/jcp.30093

Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases

J Cell Physiol. 2020 Oct 9. doi: 10.1002/jcp.30093. Online ahead of print.

Authors

Lu Yang^{1

2}, Weihua Tan^{2

3}, Xinzhi Yang^{1

2}, Yong You⁴, Jing Wang⁴, Gebo Wen^{1

2}, Jing Zhong^{1

2}

Affiliations

¹ Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan, China.
² Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
³ Emergency Department, the First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
⁴ Research Lab of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan, China.

PMID: 33090492
DOI: 10.1002/jcp.30093

Abstract

Sorting nexins (SNXs) are a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins containing the PX domain proteins. The function of SNX proteins in regulating intracellular protein trafficking consists of endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX proteins are demonstrated to be involved in several cancerous/neoplastic diseases. Here, we review the accumulated evidence of the molecular structure and biological function of SNX proteins and discuss the regulatory role of SNX proteins in distinct cancerous/neoplastic diseases. SNX family proteins may be a valuable potential biomarker and therapeutic strategy for diagnostics and treatment of cancerous/neoplastic diseases.

Keywords: cancerous diseases; neoplastic diseases; protein sorting and trafficking; sorting nexins.

Publication types

Review

Abstract

Publication types

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