Fibrin-based Bioinks: New Tricks from an Old Dog

Anastasia Shpichka; Daria Osipova; Yuri Efremov; Polina Bikmulina; Nastasia Kosheleva; Marina Lipina; Evgeny A Bezrukov; Roman B Sukhanov; Anna B Solovieva; Massoud Vosough; Peter Timashev

doi:10.18063/ijb.v6i3.269

Fibrin-based Bioinks: New Tricks from an Old Dog

Int J Bioprint. 2020 Apr 29;6(3):269. doi: 10.18063/ijb.v6i3.269. eCollection 2020.

Authors

Anastasia Shpichka^{1

2}, Daria Osipova¹, Yuri Efremov¹, Polina Bikmulina¹, Nastasia Kosheleva^{3

4}, Marina Lipina⁵, Evgeny A Bezrukov⁶, Roman B Sukhanov⁶, Anna B Solovieva⁷, Massoud Vosough⁸, Peter Timashev^{1

2

7

9}

Affiliations

¹ Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
² Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
³ Department of Molecular and Cell Pathophysiology, FSBSI Institute of General Pathology and Pathophysiology, Moscow, Russia.
⁴ Department of Embryology, Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
⁵ Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov First Moscow State Medical University, Moscow, Russia.
⁶ Department of Urology, Sechenov First Moscow State Medical University, Moscow, Russia.
⁷ Department of Polymers and Composites, NN Semenov Institute of Chemical Physics, Moscow, Russia.
⁸ Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
⁹ Institute of Photon Technologies, Federal Research Center Crystallography and Photonics RAS, Moscow, Russia.

Abstract

For the past 10 years, the main efforts of most bioprinting research teams have focused on creating new bioink formulations, rather than inventing new printing set-up concepts. New tissue-specific bioinks with good printability, shape fidelity, and biocompatibility are based on "old" (well-known) biomaterials, particularly fibrin. While the interest in fibrin-based bioinks is constantly growing, it is essential to provide a framework of material's properties and trends. This review aims to describe the fibrin properties and application in three-dimensional bioprinting and provide a view on further development of fibrin-based bioinks.

Keywords: Biofabrication; Bioink; Bioprinting; Fibrin; Regenerative medicine; Tissue engineering.

Publication types

Review