Visceral adiposity is associated with the discrepancy between glycated albumin and HbA1c in type 2 diabetes

Saori Maruo; Koka Motoyama; Tomoe Hirota; Yoshinori Kakutani; Yuko Yamazaki; Tomoaki Morioka; Katsuhito Mori; Shinya Fukumoto; Atsushi Shioi; Tetsuo Shoji; Masaaki Inaba; Masanori Emoto

doi:10.1007/s13340-020-00431-z

Visceral adiposity is associated with the discrepancy between glycated albumin and HbA1c in type 2 diabetes

Diabetol Int. 2020 Mar 21;11(4):368-375. doi: 10.1007/s13340-020-00431-z. eCollection 2020 Oct.

Authors

Affiliations

¹ Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.
² Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.
³ Department of Premier Preventive Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.
⁴ Department of Vascular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan.

Abstract

Aim: We investigated the association of visceral adiposity with glycated albumin (GA) as well as GA/hemoglobin A1c (HbA1c) in type 2 diabetes.

Methods: One hundred twenty-three patients (68 males, 55 females) with type 2 diabetes were enrolled in this cross-sectional study. Visceral fat area (VFA) was determined using an abdominal dual bioelectrical impedance analysis (dual BIA) instrument. The relationship of VFA with GA and GA/HbA1c was analyzed.

Results: Simple regression analysis showed that BMI was inversely correlated with GA as well as GA/HbA1c, but not with HbA1c, while VFA had a significant correlation with GA and GA/HbA1c. Furthermore, multiple regression analysis revealed VFA as an independent contributor to GA/HbA1c. These results suggest that visceral adiposity is a primary factor associated with GA and HbA1c level discrepancy in patients with type 2 diabetes.

Conclusions: GA is a useful indicator for glycemic control, while visceral obesity should also be taken into consideration in type 2 diabetes cases.

Keywords: Diabetes mellitus; Glycated albumin; Obesity; Visceral fat area.