PARPs' impact on base excision DNA repair

DNA Repair (Amst). 2020 Sep:93:102911. doi: 10.1016/j.dnarep.2020.102911.

Abstract

Poly(ADP-ribosyl)ation is one of immediate cellular responses to DNA damage and is catalyzed by poly(ADP-ribose) polymerases (PARPs). PARP1 is a well-known regulator of DNA repair. Another member of this family, PARP2, was discovered later. The study of PARP1 and PARP2 functions started a long time ago, and special attention has been given to the role of these enzymes in base excision repair. This review summarizes my lab's data on the functions of PARP1 and PARP2 in base excision repair as well as the results obtained in the course of our collaboration with Dr. Samuel H. Wilson.

Keywords: APE1; Base excision repair; PARP1; PARP2; Poly(ADP-ribose); Poly(ADP-ribosyl)ation; Polβ; XRCC1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism
  • DNA Damage
  • DNA Repair*
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism
  • Humans
  • Poly (ADP-Ribose) Polymerase-1 / metabolism*
  • Poly(ADP-ribose) Polymerases / metabolism*
  • X-ray Repair Cross Complementing Protein 1 / metabolism

Substances

  • X-ray Repair Cross Complementing Protein 1
  • XRCC1 protein, human
  • DNA
  • PARP1 protein, human
  • PARP2 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • APEX1 protein, human
  • DNA-(Apurinic or Apyrimidinic Site) Lyase