Phenolic compounds from the sclerotia of Inonotus obliquus

Yan-Mei Wei; Li Yang; Wen-Li Mei; Hui-Qin Chen; Cai-Hong Cai; Wei Li; Wen-Hua Dong; Zhi-Bao Chen; Hao-Fu Dai

doi:10.1080/14786419.2020.1833202

Phenolic compounds from the sclerotia of Inonotus obliquus

Nat Prod Res. 2022 May;36(9):2413-2417. doi: 10.1080/14786419.2020.1833202. Epub 2020 Oct 21.

Authors

Yan-Mei Wei^{1

2}, Li Yang^{1

2}, Wen-Li Mei^{1

2}, Hui-Qin Chen^{1

2}, Cai-Hong Cai^{1

2}, Wei Li^{1

2}, Wen-Hua Dong^{1

2}, Zhi-Bao Chen³, Hao-Fu Dai^{1

2}

Affiliations

¹ Hainan Key Laboratory for Research and Development of Natural Products from Li folk Medicine, Institute of Bioscience and Biotechnology, Chinese Academy of Agricultural Sciences, Haikou, P.R. China.
² Hainan Institute for Tropical Agricultural Resources, Chinese Academy of Agricultural Sciences, Haikou, P.R. China.
³ College of Agronomy, Guangdong Ocean University, Zhanjiang, P.R. China.

PMID: 33084385
DOI: 10.1080/14786419.2020.1833202

Abstract

Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by H₂O₂. Compound 2 showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by H₂O₂.

Keywords: Inonotus obliquus; neuroprotective activity; phenolic compound; spectroscopic analyses.

MeSH terms

Cell Line, Tumor
Humans
Hydrogen Peroxide* / pharmacology
Inonotus
Neuroprotective Agents* / chemistry
Neuroprotective Agents* / pharmacology
Phenols / pharmacology

Substances

Neuroprotective Agents
Phenols
Hydrogen Peroxide

Supplementary concepts

Inonotus obliquus