Primary Undifferentiated Pericardial Sarcoma after Radiоtherapy for Hodgkin Lymphoma

Petr V Glybochko; Victor V Fomin; Natalia V Chichkova; Evgeniya A Kogan; Andrei A Svistunov; Roman N Komarov; Abram L Syrkin

doi:10.1159/000510068

Primary Undifferentiated Pericardial Sarcoma after Radiоtherapy for Hodgkin Lymphoma

Case Rep Oncol. 2020 Sep 7;13(3):1075-1081. doi: 10.1159/000510068. eCollection 2020 Sep-Dec.

Authors

Petr V Glybochko¹, Victor V Fomin¹, Natalia V Chichkova¹, Evgeniya A Kogan¹, Andrei A Svistunov¹, Roman N Komarov¹, Abram L Syrkin¹

Affiliation

¹ I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Abstract

Various types of sarcomas arise as a result of postradiation chronic fibrous pericarditis. A primary undifferentiated spindle cell pericardial sarcoma is a rare type of sarcoma after radiotherapy. The risk of sarcoma increases with time after treatment of cancer. A 55-year-old woman underwent successful radiation and chemotherapy for Hodgkin lymphoma 20 years ago. She was hospitalized with typical manifestations of severe heart failure. Echocardiography, сomputed tomography of the chest and magnetic resonance imaging scan of the heart detected neoplastic formations of the pericardium. A biopsy of the pericardium was performed. Histological, immunohistochemical, and genetic studies showed a primary undifferentiated spindle cell pericardial sarcoma (an extremely rare type of sarcoma).

Keywords: Hodgkin lymphoma; Post-radiation fibrosis of the pericardium; Radiotherapy; Sarcoma of the pericardium; Undifferentiated spindle cell sarcoma.

Publication types

Case Reports