High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks

Bingfang Wang; Yuanyuan Luo; Lei Gao; Bo Liu; Guotao Duan

doi:10.1016/j.bios.2020.112736

High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks

Biosens Bioelectron. 2021 Jan 1:171:112736. doi: 10.1016/j.bios.2020.112736. Epub 2020 Oct 15.

Authors

Bingfang Wang¹, Yuanyuan Luo², Lei Gao², Bo Liu³, Guotao Duan⁴

Affiliations

¹ Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China; Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, China.
² Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, China; University of Science and Technology of China, Hefei, 230026, China.
³ Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China.
⁴ Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address: duangt@hust.edu.cn.

PMID: 33080461
DOI: 10.1016/j.bios.2020.112736

Abstract

Accurate detection of glucose is essential for the diagnosis of diabetes, wherein effective and sensitive biosensors for glucose detection are needed. Here, we fabricated a glucose sensor based on field-effect transistor (FET) with bimetallic nickel-copper metal-organic frameworks (Ni/Cu-MOFs) as its channel layers which were grown in-situ through a simple one-step hydrothermal method and modified with glucose oxidase (GOD) by using glutaraldehyde (GA) as linkers. Due to the synergistic effect of Ni ions and Cu ions in MOFs, the sensor (GOD-GA-Ni/Cu-MOFs-FET) showed good field effect performance and great responses to glucose through enzymatic reactions. It displayed a piecewise linear relationship in the wide range (1 μM-20 mM), and provided high sensitivity (26.05 μAcm^-2mM^-1) in the low concentration (1-100 μM) and a low detection limit (0.51 μM). The sensor also had these advantages of high specificity, excellent reproducibility, good short-term stability and fast response time. Especially, it is indicated that the Ni/Cu-MOFs-FETs with high performance have the potential to be available sensors, paving the way for the application of bimetallic MOFs in biosensing.

Keywords: Bimetallic metal-organic framework; Biosensor; Field effect transistor; Glucose detection; In situ growth method.

MeSH terms

Biosensing Techniques*
Electrochemical Techniques
Glucose
Metal-Organic Frameworks*
Reproducibility of Results

Substances

Metal-Organic Frameworks
Glucose