Multifunctional peptides for tumor therapy

Adv Drug Deliv Rev. 2020:160:36-51. doi: 10.1016/j.addr.2020.10.009. Epub 2020 Oct 17.

Abstract

Controlled nano-systems for drug delivery are designed to deliver therapeutical drugs to desirable sites on demand. Due to the diverse physiological functions of peptides, it is reasonable to introduce peptides into anti-tumor nano-system. The integration of peptides into nanomaterials has complementary advantages, which not only avoids the rapid degradation of peptides in vivo, but also improves the intelligence and functionality of the nano-system. We summarized the functional peptides with targeting and stimulus-responsive properties, and the present review outlined the most relevant and recent developed peptide-based multifunctional nanomaterials for tumor therapy.

Keywords: Drug delivery; Peptide; Stimulus-responsive; Targeting; Tumor therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacology
  • Drug Delivery Systems / methods*
  • Humans
  • Immunotherapy / methods
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy*
  • Neovascularization, Pathologic / drug therapy
  • Peptides / administration & dosage*
  • Peptides / pharmacology

Substances

  • Antineoplastic Agents
  • Peptides